Bradykinin B1 Receptor Agonist

B1R Agonist

011_B1R_F (cropped)

Product Description

Product: B1 Receptor Agonist

Metabolically stable agonist of Bradykinin B1 receptor for in vitro & in vivo preclinical research.

Sequence: NH2-Sar-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-(D-Phe)-COOH
Application: Temporary permeabilization of the blood-tumour barrier in brain cancer. diabetes research.
Disciplines: Brain cancer, drug delivery, diabetes, alzheimer’s disease research
CAS#: 1158908-54-3
Molecular weight: 1102.3 Daltons
Chemical structure: B1R Agonist Structure


Selective Opening of Blood Brain Tumor Barrier for Drug Delivery and Brain Tumor Imaging

  1. Côté J, Savard M, Neugebauer W, Fortin D, Lepage M, Gobeil F. Dual kinin B1 and B2 receptor activation provides enhanced blood–brain barrier permeability and anticancer drug delivery into brain tumors. Cancer Biology & Therapy. 2013;14(9):806-811.
  2. Côté J, Bovenzi V, Savard M, Dubuc C, Fortier A, et al. (2012) Induction of Selective Blood-Tumor Barrier Permeability and Macromolecular Transport by a Biostable Kinin B1 Receptor Agonist in a Glioma Rat Model. PLoS ONE 7(5): e37485. doi:10.1371/journal.pone.0037485

Safety and Pharmacokinetics

  1. Savard M, Côté J, Tremblay L, Neugebauer W, Regoli D, Gariépy S, Hébert N, Gobeil F. Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions.  Biol Chem 397(4): 365-372


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Bradykinin B1 Receptor Agonist