4D Imaging in Murine CV Disease Models

Time Gated Micro-CT of Mouse Cardiac Cycle

Courtesy of Dr. Timothy Doyle, Stanford University

Video of micro-CT images following IV administration of Fenestra® VC in wild type mouse. Scanning was gated on both cardiac and breath cycle, with all images acquired in the exhaled breath phase.


Cardiovascular Disease Research

  1. Vandeghinste B, Trachet B, Renard M, Casteleyn C, Staelens S, Loeys B, Segers P, Vandenberghe S. Replacing vascular corrosion casting by in vivo micro-CT imaging for building 3D cardiovascular models in mice. Mol Imaging Biol. 2011 Feb;13(1):78-86.
  2. Sheikh AY, van der Bogt KE, Doyle TC, Sheikh MK, Ransohoff KJ, Ali ZA, Palmer OP, Robbins RC, Fischbein MP, Wu JC. Micro-CT for characterization of murine CV disease models. JACC Cardiovasc Imaging. 2010 Jul;3(7):783-5.
  3. Dinkel J, Bartling SH, Kuntz J, Grasruck M, Kopp-Schneider A, Iwasaki M, Dimmeler S, Gupta R, Semmler W, Kauczor HU, Kiessling F. Intrinsic gating for small-animal computed tomography: a robust ECG-less paradigm for deriving cardiac phase information and functional imaging. Circ Cardiovasc Imaging. 2008 Nov;1(3):235-43.
  4. Detombe SA, Ford NL, Xiang F, Lu X, Feng Q, Drangova M. Longitudinal follow-up of cardiac structure and functional changes in an infarct mouse model using retrospectively gated micro-computed tomography. Invest Radiol. 2008 Jul;43(7):520-9.
  5. Drangova M, Ford NL, Detombe SA, Wheatley AR, Holdsworth DW. Fast retrospectively gated quantitative four-dimensional (4D) cardiac micro computed tomography imaging of free-breathing mice. Invest Radiol. 2007 Feb;42(2):85-94.
  6. Badea CT, Hedlund LW, Mackel JF, Mao L, Rockman HA, Johnson GA. Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. Mol Imaging. 2007 Jul-Aug;6(4):261-8.
  7. Nahrendorf M, Badea C, Hedlund LW, Figueiredo J-L, Sosnovik DE, Johnson GA, Weissleder R. High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT. Am J Physiol Heart Circ Physiol, 292(6): H3172-8, 2007.
  8. Ford NL, Graham KC, Groom AC, MacDonald IC, Chamber AF, Holdsworth DW. Time-Course Characterization of the Computed Tomography Contrast Enhancement of an Iodinated Blood-Pool Contrast Agent in Mice Using a Volumetric Flat-Panel Equipped Computed Tomography Scanner. Investigative Radiology. 41(4):384-390, 2006.
  9. Badea CT, Bucholz E, Hedlund LW, Rockman HA, Johnson GA. Imaging Methods for Morphological and Functional Phenotyping of the Rodent Heart. Toxicologic Pathology. 34:111-117, 2006.
  10. Badea CT, Fubara B, Hedlund LW, Johnson GA. 4D Micro-CT of the Mouse Heart. Molecular Imaging. 4(2): 110-116, 2005.