DHOG

DHOG (Polyiodinated Tryglicerides)

Product: DHOG (ITG)
Formula:

1,3-bis-[7-(3-amino-2,4,6-triiodophenyl)-heptanoyl]-2-oleoyl glycerol

Composition & function: ITG synthetic compounds mimic naturally occurring triglycerides that consist of long chain fatty acids – (polyiodoaryl)alkanoic acid derivatives are attached to a substituted glycerol core to provide agents capable of x-ray signal attenuation for CT imaging.  Due to their formulation properties, these compounds can be used for manufacture of a delivery vehicle such as an oil-in-water emulsion that targets hepatocytes.  These synthetic compounds can also be used to reconstitute low density lipoprotein vehicles.
Purity: Over 90%
Application: Assessing hepatocyte function, CT imaging
Disciplines: Oncology, liver disease, fatty acid metabolism
CAS#: 161466-45-1
Molecular weight: 1518.48
Chemical structure: DHOG

Publications

  1. In Vitro Assessment of Poly-iodinated Triglyceride Reconstituted Low-Density Lipoprotein
    Hill, Melissa L. et al. Academic Radiology , Volume 17 , Issue 11 , 1359 – 1365
  2. Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver. Weichert JP1, Longino MA, Bakan DA, Spigarelli MG, Chou TS, Schwendner SW, Counsell RE. J Med Chem. 1995 Feb 17;38(4):636-46.
  3. Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles.
    Bakan DA1, Weichert JP, Longino MA, Counsell RE. Invest Radiol. 2000 Mar;35(3):158-69.
  4. Computed tomography scanning of Morris hepatomas with liver-specific polyiodinated triglycerides. Weichert JP, Longino MA, Spigarelli MG, Lee FT Jr, Schwendner SW, Counsell RE. Acad Radiol. 1996 May;3(5):412-7.

Technical Documents

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