Multimodal Imaging

Multimodal Imaging

Soft-Tissue CT Data for Multimodal Molecular Imaging

Multimodal

Courtesy of Dr. David Stout, UCLA

Micro-CT without contrast, micro-CT with Fenestra® VC, co-registered contrast micro-CT and micro-PET images, micro-PET image corrected for attenuation using the non contrast enhanced CT data and micro-PET image corrected for attenuation using the Fenestra® VC enhanced CT data. The presence of Fenestra® VC does not significantly effect CT-based attenuation correction of the micro-PET images.

Multimodal

Courtesy of Dr. David Stout, UCLA

Mouse with liver tumors imaged with ~200 uCi FDG and contrast enhanced micro-CT after injection of 300 uL Fenestra® LC.

Publications

Multimodal Imaging (Models for Co-Registration)

  1. Wang H, Stout DB, Taschereau R, Gu Z, Vu NT, Prout DL, Chatziioannou AF. Epub 2012 Sep 12. MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera. Phys Med Biol. 2012 Oct 7;57(19):6063-77.
  2. Wang H1, Stout DB, Chatziioannou AF. Estimation of mouse organ locations through registration of a statistical mouse atlas with micro-CT images. Epub 2011 Aug 18. IEEE Trans Med Imaging. 2012 Jan;31(1):88-102.
  3. Zhang X, Tian J, Feng J, Zhu S, Yan G. An anatomical mouse model for multimodal molecular imaging. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:5817-20.
  4. Liang H, Yang Y, Wu Y, Boone JM, Cherry SR. MicroPET/CT system for in vivo small animal imaging. Physics in Medicine and Biology. Physics in Medicine and Biology. 52:3881-3894, 2007.

Multimodal Imaging (Cancer, Diseases)

  1. Lasnon C, Quak E, Briand M, Gu Z, Louis MH, Aide N. Contrast-enhanced small-animal PET/CT in cancer research: strong improvement of diagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4-2008 image quality parameters. EJNMMI Res. 2013 Jan 17;3(1):5.
  2. Wall JS, Kennel SJ, Richey T, Allen A, Stuckey A, Weiss DT, Macy SD, Barbour R, Seubert P, Solomon A, Schenk D. Generation and characterization of anti-AA amyloid-specific monoclonal antibodies. Front Immunol. 2011 Aug 8;2:32.
  3. Gabie de Jong, Thijs Hendriks, Rob Bleichrodt, Martin Gotthardt, Eric Visser, Wim Oyen and Otto Boerman. FDG-PET, CT and MRI for the detection of experimental colorectal liver metastases: An exploratory study. J Nucl Med. 2011; 52 (Supplement 1):312
  4. Tsui B, Mok G, Wang Y, Taso A, Bedja D, Yu J, Gabrielson K, Nimmagadda S, Bengal F, Pomper M. High-resolution small animal SPECT/CT imaging of atherosclerotic plaques in ApoE-/- mice using Tc-99m Annexin-V and contrast enhanced CT. J Nucl Med. 2007; 48 (Supplement 2):103P
  5. Tsui B, Mok G, Wang Y, Taso A, Bedja D, Yu J, Gabrielson K, Nimmagadda S, Bengal F, Pomper M. High-resolution small animal SPECT/CT imaging of atherosclerotic plaques in ApoE-/- mice using Tc-99m Annexin-V and contrast enhanced CT. J Nucl. Med. 48(S2):103P, 2007.
  6. Wall JS, Kennel SJ, Paulus M, Gregor J, Richey T, Avenell J, Yap J, Townsend D, Weiss DT, Solomon A. Radioimaging of light chain amyloid with a fibril-reactive monoclonal antibody. J Nucl Med. 2006 Dec;47(12):2016-24.
  7. Avenell, J. Evaluating non-invasive microPET/CT imaging of K-562 myelosarcoma for monitoring tumor growth and angiogenesis in untreated and treated mice. J Nucl Med. 2006; 47 (Supplement 1):556P
  8. Isobe s, Tsimikas S, Zhou J, Fujimoto S, Sarai M, Branks MJ, Fujimoto A, Hofstra L, Reutelingsperger CP, Murohara T, Virmani R, Kolodgie FD, Narula N, Petrov A, Narula J. Noninvasive Imaging of Atherosclerotic Lesions in Apolipoprotein E-Deficient and Low-Density-Lipoprotein Receptor –Deficient Mice with Annexin A5. J Nucl Medicine. 2006 47:1497-1505.
  9. Wall JS, Kennel SJ, Paulus MJ, Gleason S, Gregor J, Baba J, Schell M, Tichey T, O’nuallain B, Donnell R, Hawkins PN, Weiss DR, Solomon A. Quantiitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis. Amyloid: The Journal of Protein Folding Disorders. 12(3):149-156, 2005.
  10. Aykac D, Price JR, Wall JS. 3D Segmentation of the Mouse Spleen in microCT via Active Contours. 2005 IEEE Nuclear Sciences Symposium Conference Record. M03-91, p1542-1545.
  11. Weichert JP, Perlman SB, Lee FT, Johnson CD, Coyle TM, Bennet L. Comparison of a hepatocyte-selective polyiodinated triglyceride CT contrast agent and FDG-PET in the woodchuck model of spontaneous hepatocellular carcinoma. Radiologic Society of North America, 87th Annual Meeting, Chicago IL, 2001.