Mvivo Au

Mvivo Au Web

Mvivo Gold Nanoparticles
Product: Colloidal gold contrast for small animal micro-CT imaging
Description: Colloidal gold contrast agent for high resolution microCT angiography and tumor imaging. Offered exclusively by MediLumine and co-developed with Cytodiagnostics Inc., a leader in manufacture of gold nanoparticles for Biology and Medicine.
Application: Micro-CT angiography and tumor imaging.
Disciplines: Oncology
Particle size:  14 ±2 nm
Concentration: 200 mg/ml
Optical density: 3500
Storage buffer: 10 mM Phosphate Buffered Saline (1x PBS)
Product information:  Certificate of Analysis

Applications

Micro-CT Tumor Imaging

Image shows Mvivo™ Au nanoparticle uptake in brain tumor following IV injection (dose of 0.1 ml per 20 grams) into a NUDE mouse glioblastoma tumor transplant model established with injection of U251 stem cells. The blood pool contrast agent diffuses into extracellular space of tumor and enables longitudinal micro-CT imaging of tumor after a single injection. Image courtesy of CROmed.

Micro-CT Angiography

3D reconstruction of mouse brain vasculature from µCT measurements acquired with Siemens Inveon multimodal imaging system. Courtesy of Dr. Michael Lamba, University of Cincinnati.

Mvivo Au Long Last micro-CT Contrast

Axial slice showing vascular contrast for microCT scan 26 hours post-injection of Mvivo™ Au at doses of 0.1 ml (right), 0.15 ml (left), and 0.2 ml (top). Image courtesy of Dr. Timothy Doyle, Stanford University

Publications

micro-CT Imaging of Rodent Brain Vasculature

  1. C Tipton, M Lamba, Z Qi, K LaSance and C Tipton Micro-CT Based Quantification of Mouse Brain Vasculature: The Effects of Acquisition Technique and Contrast MaterialMed. Phys. 43, 3459 (2016)