Fenestra® Imaging Agents

Fenestra® is a licensed technology that solves several key problems associated with micro-CT imaging. This biochemically activated emulsion is comprised of iodinated lipids that provide contrast enhancement and a novel oil-in-water lipid emulsion that selectively localizes the lipids for small animal imaging. The unique Fenestra® formulation is biodegradable and completely eliminated by hepatocyte metabolism.

Mvivo™ Imaging Agents

Mvivo™ is our nanoparticle contrast agent line of products for in-vivo imaging. These contrast agents are are ideal for applications such as targeted imaging, vascular and tumor imaging, techniques that require high resolution contrast agents to match the higher resolution preclinical imaging modalities:

Bradykinin Receptor Modulators

Based on a proprietary sequence of natural and unnatural amino acids, the biostable B1R agonist for blood brain tumor barrier (BBTB) permeabilization, B2R for general blood brain barrier permeabilization and B1R/B2R agonist for optimum BBTB/BBB permeabilization are available exclusively through MediLumine.  MediLumine offers three different peptide agonists which are ideal for co-injection with other contrast agents and possible therapeutic compounds to cross the blood brain barrier.

These agonists can also be used for other applications since recent publications have shown that they are expressed in other disease states.

Systems & Accessories

MediLumine™ offers accessories and high quality hardware solutions for challenging aspects of preclinical in vivo research such as control/maintenance of animal body temperature during experimental surgery, high quality anesthesia and performing successful tail vein injection:


Chemical Opening of Blood Brain Barrier

Representative intravital confocal images of a mouse brain microvasculature following i.v. injection of FITC-Dextran (MW 2 MDa) (A) and 30 min post-injection of MediLumine’s B2R agonist (0.050 mg/kg or 1.25 μg/mouse) showing extrasavation of FITC-Dextran (B). Scale represents the intensity of fluorescence (Courtesy of Drs Martin Lepage and Fernand Gobeil).





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  2. Akladios CY, Bour G, Raykov Z, Mutter D, Marescaux J and Aprahamian M. Structural imaging of the pancreas in rat using micro-CT: application to a non-invasive longitudinal evaluation of pancreatic ductal carcinoma monitoring. J Cancer Res Ther. 2013, 1(2): 70–76
  3. Akladios CY, Bour G, Balboni G, Mutter D, Marescaux J, Aprahamian M. [Contribution of microCT structural imaging to preclinical evaluation of hepatocellular carcinoma chemotherapeutics on orthotopic graft in ACI rats]. Bull Cancer. 2011 Feb;98(2):120-32. doi: 10.1684/bdc.2011.1303.
  4. Martiniova L, Schimel D, Lai EW, Limpuangthip A, Kvetnansky R, Pacak K. In vivo micro-CT imaging of liver lesions in small animal models. Methods 50 (2010) 20–25
  5. Kitahashi T, Mutoh M, Tsurusaki M, Iinuma G, Suzuki M, Moriyama N, Yoshimoto M, Wakabayashi K, Sugimura T, Imai T. Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X-ray micro-computed tomography (CT). Cancer Sci. 2010 Jul;101(7):1761-6. Epub 2010 Apr 7.
  6. Rampurwala M, Ravoori MK, Wei W, Johnson VE, Vikram R, Kundra V. Visualization and quantification of intraperitoneal tumors by in vivo computed tomography using negative contrast enhancement strategy in a mouse model of ovarian cancer. Transl Oncol. 2009 May;2(2):96-106.
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  1. Fernandes PD, Gomes N de M, Sirois P. The bradykinin B1 receptor antagonist R-954 inhibits Ehrlich tumor growth in rodents. Peptides. 2011 32: 1849–1854
  2. Kaufman GN, Zaouter C, Valteau B, Sirois P, Moldovan F. Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis. Arthritis Research & Therapy. 2011;13(3):R76. doi:10.1186/ar3338.
  3. Catanzaro O., Capponi J. A., Michieli J., Labal E., Di Martino I., Sirois P. (2013). Bradykinin B(1) antagonism inhibits oxidative stress and restores Na+K+ ATPase activity in diabetic rat peripheral nervous system. Peptides 44, 100–104. 10.1016/j.peptides.2013.01.019
  4. Catanzaro O, Labal E, Andornino A, Capponi JA, Di Martino I, Sirois P. Blockade of early and late retinal biochemical alterations associated with diabetes development by the selective bradykinin B1 receptor antagonist R-954. Peptides. 2012;34:349–352.
  5. Catanzaro OL, Dziubecki D, Obregon P, et al. Antidiabetic efficacy of bradykinin antagonist R-954 on glucose tolerance test in diabetic type 1 mice. Neuropeptides. 2010;44:187–189.
  6. Vasquez-Pinto L. M., Nantel F., Sirois P., Jancar S. (2010). Bradykinin B(1) receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-beta and VEGF in a murine model of asthma. Neuropeptides 44 107–113

Selective Opening of Blood Brain Tumor Barrier for Drug Delivery and Brain Tumor Imaging

  1. Côté J, Savard M, Neugebauer W, Fortin D, Lepage M, Gobeil F. Dual kinin B1 and B2 receptor activation provides enhanced blood–brain barrier permeability and anticancer drug delivery into brain tumors. Cancer Biology & Therapy. 2013;14(9):806-811.
  2. Côté J, Bovenzi V, Savard M, Dubuc C, Fortier A, et al. (2012) Induction of Selective Blood-Tumor Barrier Permeability and Macromolecular Transport by a Biostable Kinin B1 Receptor Agonist in a Glioma Rat Model. PLoS ONE 7(5): e37485. doi:10.1371/journal.pone.0037485

Safety and Pharmacokinetics

  1. Savard M, Côté J, Tremblay L, Neugebauer W, Regoli D, Gariépy S, Hébert N, Gobeil F. Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions.  Biol Chem 397(4): 365-372
  2. Savard M, Côté J, Tremblay L, Neugebauer W, Regoli D, Gariépy S, Hébert N, Gobeil F. Preclinical pharmacology, metabolic stability, pharmacokinetics and toxicology of the peptidic kinin B1 receptor antagonist R-954. Peptides. 2014 Feb;52:82-9. doi: 10.1016/j.peptides.2013.12.009. Epub 2013 Dec 18.