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MediLumine’s EMCCD based PRISM™ uses photon counting for highly sensitive in vivo optical imaging. The imager is able to detect a single photon in a pixel opening a new biological window for bioluminescence and fluorescence imaging.
In addition, the imaging system is sensitive at high acquisition speeds allowing for real-time imaging in bioluminescent and fluorescence modes.
The example below shows PRISM™ in vivo detection of near-infrared photons from bioluminescent tumor expressing luciferase. In this example, PRISM was able to detect an average of 5 near-infrared photons per pixel for a 10-second acquisition.
User’s of PRISM are finding that the system has an unparalleled combination of real-time imaging and detection of ultra-weak photonic emissions for deeper and earlier in vivo imaging.