A benchmark study for the time course of contrast enhancement of Fenestra® VC was performed on a flat-panel eXplore Locus and an injection dose of 10 mL/kg. Peak enhancement in C57 mice hearts occurred 0.25 hours with a 340 HU enhancement over baseline. Contrast enhancement in the liver reached a value of 290 HU over baseline at the 24 hour time point. Elimination of contrast from the blood pool was calculated to be 8 hours.
The time course of Fenestra® VC makes it ideal for prolonged vascular imaging and retrospective cardiac gating studies.