Time Course of Contrast Enhancement Using Fenestra VC

One challenge for development of non toxic micro-CT contrast agents is to load a high concentration of an X-ray attenuating element in a nanoparticulate formulation with particle size distribution small enough to avoid accumulation in lungs but large enough to avoid kidney filtration.  Binitio Biomedical’s Exia 160 and Exia 160XL meet these requirements with sufficient stealth properties for vascular imaging. In addition, they are made of components which are metabolized by catabolic pathways in the body thus enabling metabolic imaging of the myocardium and brown adipose tissue.

Comparison of differential enhancement at 15 min and 4 h post injection of eXIA 160 in a control mouse for both  filtered micro-CT and dual-energy (DE) calcium/iodine decomposed maps with iodine in red and calcium in green. Axial (A) and coronal (B) slices through the center of the left ventricle are shown. The CT images are windowed between500 and 750 HU and the DE maps have iodine windowed between 1.5 and 10 mg mlexp-1 and calcium between 0 and 50 mg mlexp-1. The arrows show brown adipose tissue.

Credit:

Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agentJeffrey R. Ashton. et al. Contrast Media Mol. Imaging 2014, 9 161–168. DOI: 10.1002/cmmi. 

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