Tips for Achieving Successful Tail Vein Injections

Achieving successful tail vein injections is no easy task.  As seen in image below, the veins are small and there is a lot of room for error. To help researchers with this challenging task, MediLumine has developed Mvein restrainer for tail vein injections.

With Mvein, the mouse is loaded head first and can be rotated 90 degrees so that tail is lifted in position for injection. The head is immobilized to prevent asphyxia. 

For the procedure, we recommend taking the ‘aloha’ surfer salutation approach to holding the syringe and use smaller syringes to fit size of hand if necessary. i.e. hold the syringe between the thumb and index finger, and push the plunger with pinky (for large volume) or ring finger (less volume). Do not hold the syringe like a cigarette because there is much less control with this handling method.

Image showing mouse lateral and dorsal tail veins for IV injection

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